The Diclonius, a mutated homo sapien that is said to be selected by God and will eventually become the destruction of mankind, possesses two horns in their heads, and has a "sixth sense" which gives it telekinetic abilities. Due to this dangerous power, they have been captured and isolated in laboratories by the government. Lucy, a young and psychotic Diclonius, manages to break free of her confines and brutally murder most of the guards in the laboratory, only to get shot in the head as she makes her escape. She survives and manages to drift along to a beach, where two teenagers named Kouta and Yuka discovers her. Having lost her memories, she was named after the only thing that she can now say, "Nyuu," and the two allow her to stay at Kouta's home. However, it appears that the evil "Lucy" is not dead just yet...

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Sauerland, autumn 1995: In the middle of the forest on the Wilzenberg, a walker finds the body of high school graduate Sonja Risse. However, the fact that the killer left a music box with the lullaby "Hush Little Baby" at the crime scene does not lead to a clear solving. 25 years later, the investigative journalist Stefanie Schneider, known as "Mütze", made a surprising discovery in Cologne. In a disused multi-storey car park, she films an undressed corpse of a man with a music box running next to it! When her colleague Jan Römer, who reported on the spectacular Sonja case as a young journalist in 1995, recognizes the melody from back then, he immediately believes there is a connection. He goes to Wilzenberg with his ambitious colleague to interview Sonja's mother Maria, her former teacher Waldheim and her best friends. The more the journalists compile, the clearer the contradictions and gaps that the investigators should have noticed at the time.